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Both the European Association of Urology and SIAMS guidelines identify intracavernosal alprostadil as the treatment of choice for patients who do not respond to PDE5-Is, including those with advanced diabetic neuropathy [36,42]

Clenbuterol also induces marked increases in plasma concentrations of several substrates and hormones, including glucose (25%), lactate (87%), insulin (105%), and free fatty acids (129%), reflecting widespread systemic metabolic activation [1]

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