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Amongst the different factors that protect the cell against OS, the members of the glutathione S-transferase (GST) superfamily play an important role

However, it is important to note that increasing glutathione levels should be done cautiously, as there may be risks associated with it

Furthermore, expression profiling using real-time PCR, western blotting and GSTM2 overexpression following transient knockdown of GSTM1 in HeLa cells confirmed that the absence of GSTM1 activity can be compensated for by the overexpression of GSTM2.

Elisa DellAglio1 and Amna Mhamdi2 1 Institut National des Sciences Appliques-Lyon, 69100 Villeurbanne, France 2 Ghent University, Department of Plant Biotechnology and Bioinformatics