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In PD, misfolded syn and neuronal damageassociated molecules (e.g., ATP, HMGB1) activate microglia through pattern recognition receptors including TLR2 and TLR4 [14], triggering a proinflammatory phenotype with cytokines (TNF and IL1) and ROS release [15]

Acknowledgements This work was supported by the National Key R & D Program of China (Grant No

The acidic pH inside lysosomes is crucial for the activation of hydrolytic enzymes, enabling efficient degradation of cellular components during autophagy [84]

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Some practitioners implement cycling to theoretically prevent receptor desensitization, provide physiological breaks, or manage costs, though evidence supporting these approaches is limited

Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone) Proc