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BAP1 is a nuclear deubiquitinase (DUB) that removes histone 2A mono-ubiquitination (H2Aub) at lysine 119, a histone modification that is generally associated with transcriptional repression (Wang et al., 2004

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Importantly, this approach does not target GPX4 directly but instead starves it of its functional substrate, rendering the enzyme catalytically inert and exposing the membrane to unmitigated lipid peroxidation

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PI3K, RSK, and mTOR signal networks for the GST gene regulation