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The Future of Brain Repair Research into neurotrophic factors is accelerating
A similar approach known as protein misfolding cyclic amplification was used by Soto and colleagues 89
Col4a1 mutations impair the folding of collagen IV and its trafficking through the endoplasmic/sarcoplasmic reticulum, and secretion of collagen IV to the basement membranes is reduced

Functionally analogous are the Peroxiredoxins (Prx) , which use the same mechanism but with a cysteine active site that shuttles from the thiolate (S-H) to the sulphinic acid (S-OH) form and is reduced back by glutathione

However, these findings are based on preclinical studies, and the effectiveness of BPC 157 in humans is still under investigation
