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Soileau, M

In addition, we also assessed the intracellular levels of reduced GSH and observed a significant reduction in these levels in HK-2 cells H 2 O 2 stimulation compared with those in normal cells (Figure 3G)

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Furthermore, acetylcholine-induced production of bioavailable nitric oxide was lower in aortic rings from GPx1 / ApoE mice than ApoE / mice, and the double knockout mice had increased 3-nitrotyrosine staining in atheromatous plaques, similar to earlier findings of endothelial dysfunction in GPx1-deficient mice [39, 70, 71]