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Aw TY, Wierzbicka G, Jones DP

The reproductive system is particularly vulnerable to reactive oxygen species (ROS)-induced stress due to its unique structural and metabolic characteristics

In renal clear cell carcinoma, disulfiram demonstrated potent antitumor activity by inhibiting NPL4, promoting oxidative stress, and inducing ferroptosis ( Furthermore, combination therapy with disulfiram and conventional chemotherapeutic agents (e.g., PARP inhibitors, sorafenib, doxorubicin) has demonstrated synergistic effects in vitro and in animal models, partially overcoming tumor resistance and improving therapeutic efficacy ( Through co-delivery via nanocarriers, precise release of disulfiram and metal ions can be achieved, enhancing drug stability and tumor targeting while reducing systemic toxicity ( 6 Conclusion and outlook As a major threat to mens health, urological cancers have shown an increasing incidence trend in recent years

the relationship between high TMAO levels and cardiovascular risk remains scientifically debated with moderate evidence levels

The interruption of metabolic support directly translated to impaired regeneration in vivo

doi: 10.1073/pnas.091016398