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This temporal pattern suggests that acute social stress alone may be insufficient to produce persistent anxiety-like phenotypes, highlighting the importance of stress intensity and cumulative exposure in shaping long-term behavioral outcomes

The prevalence of B12 deficiency increases significantly after age 60, and correcting deficiency can help maintain normal neurological function

& Karpiski, T

ZhaoJHuangWZhangSXuJXueWHeBet al

PCC usually displays little signs and symptoms in the early stage but rapid progression to the advanced stage, which lead to difficulty in early diagnosis and poor prognosis [82, 83]

10.1007/s00253-007-1277-1