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Pathway enrichment analysis revealed that these genes were enriched in 170 signaling pathways, and the top 20 signaling pathways most closely related to AD were the following (Supplementary Table 2): AD-related pathways include neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, calcium signaling pathway, cAMP signaling pathway, MAPK signaling pathway, Ras signaling pathway, serotonergic synapse, pathways of neurodegeneration multiple diseases, Rap1 signaling pathway, AD and AGE-RAGE signaling pathway in diabetic complications

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This idea was confirmed by the finding that inactivated vaccine, such as the Salmonella cells killed by peracetic acid, reduces the formation of reservoirs of persisters after oral infection with S

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Zinc finger MYND type 8-containing (ZMYND8), an epigenetic reader, interacts with SREBP2 to activate the MVA pathway and promotes intestinal stemness and tumorigenesis 113,114

Antioxidants SOD and POD is an essential antioxidant enzyme that catalyzes the dismutation of superoxide radicals (O 2 -) into molecular oxygen (O 2 ) and hydrogen peroxide (H 2 O 2 ) [73]