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Therefore, the combinational suppression of both GLUT1 and NF-B by T-AsiG-CPL realized the dual intervention of PDAC cells and PSC and co-blocking of major energy metabolic pathways (glycolysis and OXPHOS) in PDAC (Fig

Firstly, restricted carbohydrate intake in KD leads to a reduction in glycolysis, the primary pathway of glucose catabolism, which is responsible for the production of NADH (140)

Due to its disagreeable flavor, NAC is often mixed with fruit juice or a soft drink prior to consumption

10.1021/am401285x 84 ParkK

During carcinogenesis, cancer cells can utilize the mitophagy pathway to increase their metabolic demand and resistance to cell death, leading to increased proliferation and invasive capacity of cancer cells [35]

Treatment protocols differ