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Moreover, genes implicated in energy metabolism are overexpressed in SNc neurons, such as ATP Synthase F1 Subunit Alpha ( ATP5F1A ), Ubiquinol-Cytochrome C Reductase Core Protein 1 ( UQCRC1 ), and Dehydrogenase E1 Subunit Alpha 1 ( PDHA1 ) that participated in OXPHOS and Pyruvate Kinase ( PKM ), Enolase 3 ( ENO3 ), and Enolase 1 ( ENO1 ) crucial in glycolysis (Table 1) (Greene et al., 2005)

Science 368 , 11271131 (2020)

Chromatin remodeling factors, such as HELLS, suppress ferroptosis by altering the expression of lipid metabolism genes like SCD and FADS2, which regulate monounsaturated fatty acid (MUFA) synthesis to counteract lipid peroxidation [81,82,83]

The examples of mellitin, collagen and hemoglobin, shown below demonstrate this feature

59 HirashimaY.TsuruzoeK.KodamaS.IgataM.ToyonagaT.UekiK.et al (2003)

One important aspect that influences the bioavailability of folate from dietary sources is the glutamate chain present in the molecule [63]