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Garber JR, Cobin RH, Gharib H, Hennessey JV, Klein I, Mechanick JI et al (2012) Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association
Furthermore, the activation of apoptosis markers such as Caspase 3 and pronounced DNA fragmentation not only impair sperm motility but also reduce the success rates of sperm oocyte binding and fertilization, these pathological alterations consequently lead to increased incidence of embryonic mortality or malformation [43]