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With rigorous methodology, biomarker guided enrollment, optimized delivery, and careful safety monitoring, antioxidant-oriented interventions can progress from complementary approaches to validated therapeutic options that complement existing standards of care for defined ASD endophenotypes

[DOI] [PMC free article] [PubMed] [Google Scholar] 98.Wijnands K.A., Meesters D.M., van Barneveld K.W., Visschers R.G., Bried J.J., Vandendriessche B., van Eijk H.M., Bessems B.A., van den Hoven N., von Wintersdorff C.J., et al

Lastly, it is important to remark that ED could represent an early predictor of CV events and the diagnosis of vasculogenic ED at PDU, and particularly at dynamic PDU as the gold standard diagnostic tool, both in patients with or without additional CV risk factors and/or comorbidities, can help to recognize eventual arterial diseases in biggest distal vessels [35, 39,40,41]