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doi: 10.1002/jat.4094 36 KanskaJAspuriaPPTaylor-HardingBSpurkaLFunariVOrsulicSet al

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Gap-PPI deficits in noise-exposed animals (defined as an index score exceeding the 95% CI) indicated that 38 of the 66 animals developed tinnitus, resulting in an overall incidence rate of 58%

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Elevated NNMT activity results in the depletion of nicotinamide and S-adenosylmethionine (SAM) , disrupting NAD+ biosynthesis and methylation processes essential for metabolic balance (Kraus D, 2014)
