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3c,d and Supplementary Fig

Dose reduction community sources describe halving the per-injection dose when flushing or metallic taste becomes too intrusive, then re-evaluating at 2 weeks

The expression of apelin (an endogenous ligand of apelin/apelin receptor (APJ) can alleviate endothelial cell dysfunction in DKD) is increased in STZ-induced diabetic mice, but the expression of APJ is decreased

PNAS 2019;116:27016 Volterra A, Trotti D, Tromba C, Floridi S, Racagni G
56,57 Iron content in skeletal muscle increases with age

This oxidative stress therefore represents a key mechanism underlying the adverse health effects of PM exposure, including respiratory and cardiovascular diseases [143]
