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Cholinergic urticaria and hypohidrosis: a clinical reappraisal

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The gut microbiome further modulates MRIS progression via metabolites like trimethylamine N -oxide (TMAO), influencing platelet reactivity [13]
The intrinsic pathway can be triggered either as a result of mPTP opening, or activation of the proapoptotic proteins of the B-cell lymphoma 2 (Bcl-2) family, Bax and Bak [192] after the removal of the block of antiapoptotic proteins Bcl-2 and Bcl-XL [193]
