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According to Table 3 , a characteristic pro-inflammatory state can be observed in SZ patients, manifested by persistently elevated levels of pro-inflammatory cytokines such as IL-6, IL-1, and TNF- in both peripheral blood and CSF, accompanied by a relative deficiency of anti-inflammatory cytokines like IL-10 and TGF-

10.1002/adma.201604100

As a result, they are widely believed to suffer from poor membrane permeability and inefficient cellular uptake---mechanisms that remain poorly understood

In contrast, AEA and DHEA, which are derived from AA and omega-3 fatty acids [3 FAs], respectively, and associated with beneficial cardiovascular, neurological and anti-inflammatory effects (63), were lower in those with prior COVID-19 compared to nave controls

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They are the architecture that makes the clinical outcomes possible