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Sikiric et al [44] reported that following induced hepatic injury (hepatic artery ligation, bile duct ligation, or carbon tetrachloride administration), all BPC-157 pretreated rat groups (regard- less of dose and timepoint) had a similar reduction of ala- nine transaminase (AST), bilirubin, and AST-to-aspartate transaminase (ALT) ratio and less histologic evidence of liver necrosis compared to saline pretreated controls