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[9] The original N-terminally modified variants of this type, including LR3IGF-I and the related des(1-3)IGF-I, were shown to be consistently several-fold more potent than native IGF-1 in animal tissue-growth assays, a difference attributed directly to their reduced interaction with binding proteins

This regulatory function occurs via macrophage polarization in response to both internal and external environmental or pathological stimuli (Ying et al

J Clin Invest, 83: 314-316

Molecular hydrogen: a preventive and therapeutic medical gas for various diseases

E.Sauri-DuchE.Zapata-PrezO.SantamaraJ

2004 Nov;111(11):1993-2006