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Chemotherapy-induced injury of organ tissue is the culprit, Whitehead Institute Founding Member Robert Weinberg and colleagues have found.

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We show that up to 89% of the erythrocyte glutamate pool can be derived from ALT and that ALT-derived glutamate is subsequently used for glutathione synthesis.

Here, we demonstrate that TNBC cells exhibit sensitivity to individual nutrient deprivation but can survive dual cystine and glutamine deprivation via distinct mechanisms