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It was demonstrated that the inhibition of Drp1 activity resulted in a reduction of cell death, as observed in studies where mutant SOD1 or TDP-43 were introduced into the system (Nemtsova et al

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In recent years, emerging strategies in regenerative medicine, such as stem cell therapy, dedicated to restoring disc structure and function at the cellular and molecular levels, have brought new hope for achieving disease-modifying therapies (Table 2)

This means ARA-290 provides EPO's tissue-protective benefits without the serious risks of polycythemia, increased blood viscosity, and cardiovascular events that limit EPO use

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