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[DOI] [PMC free article] [PubMed] [Google Scholar] 89.Kakov ., Hlavov J., Flegr J

Functional studies demonstrate that pathogenic E50K mutation in OPTN increases RGC susceptibility to cell death, which can be rescued by the TBK1 inhibitor Amlexanox [235]
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Antiproliferative Effect of Scutellaria Barbata D

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The high temperature levels increase the kinetic energy which break, in turn, the bond between active amino acids, causing loss of enzyme activity [65]