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A triple-hormone-receptor agonist, retatrutide , awaits FDA approval

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Despite the absence of GLP-1Rs on hepatocytes, GLP-1 is involved in hepatic lipid and glucose metabolism, by contributing to fibrosis reversal and liver cells protection in patients with nonalcoholic steatohepatitis (NASH) undergoing GLP-1 RAs (35)

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This correlation does not tell us whether the symptom improvement was driven by weight loss, direct anti-inflammatory effects, or both, but it confirms that the metabolic improvements tracked alongside the symptom improvements