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DNA methylation inhibitors in the treatment of leukemias, myelodysplastic syndromes and hemoglobinopathies: clinical results and possible mechanisms of action

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In a typical off-the-shelf CAR-T product, T cell receptor (TCR) and/or Major Histocompatibility Complex (MHC) genes are knocked out using gene-editing tools like TALENs or CRISPR/Cas9 (3436)

Keywords: atypical presentation, epigastric pain, erosive gastritis, helicobacter pylori, lower lobe consolidation, pneumonia Introduction Pneumonia is a common, potentially fatal infection, affecting approximately 450 million people and causing nearly four million deaths annually worldwide, with the highest burden observed in children under five years and older adults [1,2]