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This dual actionreducing oxidative stress while preventing apoptosismakes Pinealon particularly effective for neuronal protection

QR2 is one of the reductases that help protect against oxidative stress by blunting quinones electron transfer reactions [161].In addition, melatonin binds to a family of nuclear receptors called the retinoid-related orphan (ROR) receptors [162], which are involved in the regulation and modulation of the circadian clock [163]

This is a clinical and medicolegal imperative

Ultrastructural evidence for hair cell regeneration in the mammalian inner ear

doi: 10.1128/AEM.01259-15 73 RueppellO.ChristineS.MulcroneC.GrovesL

M., Nofziger, C., Dossena, S., Paulmichl, M