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FIGURE 2 Discussion We here show that MTII inhibited caloric intake to a larger extent in rats on the fcHF diet compared to rats on the CHOW, fcHFHS, or fcHS diet

It's usually mild, dose-dependent, and improves with subsequent doses

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Haddad HW, Mallepalli NR, Scheinuk JE, et al

When creatine isnt fully dissolved, it may remain in the digestive tract longer, as mentioned in the above-linked 2025 review, pulling in water and potentially leading to GI symptoms like bloating

doi: 10.1016/j.antiviral.2014.02.011
