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Group II was the autistic model group and was treated with 250 mg PPA to model a neurological insult that might lead to autism

290(11): 15004 Roby CA, Dryer DA, Burstein AH

& Powell, M
Epub 2019 Nov 7

10.1146/annurev.bi.57.070188.001401 [DOI] [PMC free article] [PubMed] [Google Scholar] 15

Historical background of RNA-based therapeutics Significant advancements in gene sequencing technology have been made after the completion of the human genome project in 2003, which deepened our understanding of genetic causes for different diseases (Goodwin et al., 2016) and paved the way for the development of RNA-based therapeutics, which target disease-related genes that could not be targeted by conventional drugs, small molecules or protein-based drugs (Kaczmarek et al., 2017)
