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doi: 10.2527/2006.8413_supplE155x 43 SinghS

These results suggest that PARG inhibition is effective for not only degrading BRD family proteins but also degrading another chromatin regulator, CDK9

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This oxidative damage is particularly severe in the substantia nigra in PD, where dopamine-producing neurons are especially vulnerable to ROS ( 2.4 Neuroinflammation Neuroinflammation is another critical factor in the progression of neurodegenerative diseases