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10.1080/10408444.2020.1719974 9 BanksW

Following a 6-wk ethanol feeding, the levels of expression and activity of these enzymes in KO and WT mouse livers were comparable

3D culture models with CRISPR screens reveal hyperactive NRF2 as a prerequisite for spheroid formation via regulation of proliferation and ferroptosis

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GPx-1 may also be transcriptionally upregulated as part of the cellular response to oxidative stress

Taken together, these findings suggest that NAC can cross the intact BBB but then is rapidly eliminated via OAT1 and OAT3 (and perhaps other probenecid-inhibitable membrane transporters)