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Early identification of these mutations through genetic workups not only supports accurate diagnosis but also allows for prompt and tailored treatments, as summarized in Table II, which compares treatment modalities, their mechanisms, genotype associations, effectiveness and limitations (17,38)
Moreover, there might be modulatory effects on the prostaglandins system [2,3,4,5,6,7,8,74]

The paracetamol nomogram is not useful 3

2D), alisertib [40, 41] (Aurora kinase A inhibitor, Supplemental Fig

Nitric oxide donors and cardiovascular agents modulating the bioactivity of nitric oxide: An overview
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doi: 10.1016/j.jocn.2019.11.021 235
