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This endothelial damage can worsen glucose metabolism disturbances in DKD patients, leading to concurrent brain dysfunction and kidney impairments due to their common vulnerabilities to endothelial injury

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Effect of enriching the diet with menhaden oil or daily treatment with resolvin D1 on neuropathy in a mouse model of type 2 diabetes

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Indeed, when GSAAT is reduced with gradually increasing amounts of DTT prior to incubation with NEM, either one Cys (Band 1, with 0.1 mM DTT) or no Cys residue of GSAAT is accessible for mPEG binding (with DTT 1 mM) ( Figure 2C )