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coli [73] and Rhizobium tropici [74] cells from acid challenge by regulation of gated potassium export channels KefB and KefC, restricting transport of K + ions and thus maintaining the cytoplasmic pH

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Its activity profile is best understood as systems-level: published in vitro and in vivo work has documented effects on fibroblast proliferation, collagen and growth-factor receptor expression, endothelial migration, nitric oxide system signalling, and dopamine and serotonin pathway markers