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Among its isoforms, NOX2 is predominantly expressed in Kupffer cells and is activated via toll-like receptor 4 (TLR4) signaling, resulting in superoxide production and pro-inflammatory cytokine release [113, 114]

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[DOI] [PubMed] [Google Scholar] 252.Dekhuijzen P.N., Aben K.K., Dekker I., Aarts L.P., Wielders P.L., van Herwaarden C.L., Bast A

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