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This is the reason why drugs that are orally administered as sustained-release, extended-release, or other time-release formulations have an artificially lengthened half-life

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developed NPs decorated with acetylcholine and choline analogs to simultaneously target CTL1 and nicotinic acetylcholine receptors (nAChRs), reporting a 42-fold increase in brain accumulation of bovine serum albumin and uniform distribution in the neuronal extracellular space 24 h post-administration [213]

T cells and NK cells express several cell surface co-stimulatory receptors which belong to TNFR family that induce the effector function of T cells and NK cells in tumor environment