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The scenario is discussed in terms of the deregulation of carnitine traffic/homeostasis in human cancers

Untreated and undiagnosed cases can result in sudden death

Shao YT, Chuang SY, Chang HY, Tseng YC, Shao KT

Caspases, which are cysteine-dependent aspartate-directed proteases regulated by Bcl-2 family proteins, heat shock proteins, and apoptosis inhibitors, become active in the cytosol upon activation and then cleave a wide range of proteins, are common features of the diverse routes leading to apoptosis ( Fig

Without sufficient carnitine, fatty acids cannot efficiently enter the mitochondria (even if there are abundant fat stores)

doi: 10.1007/s10545-011-9289-5