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The enzyme protomer adopts a distorted jelly-roll fold composed of a -sheet core flanked by -helices, as previously described

Inhibition of TGR was shown in biochemical assays with recombinant protein, and in ex vivo worms by measurement of both TGR-generated fluorescent products from TRFS-Green and the decrease in the GSH/GSSG ratio

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Cluster of orthologous groups (COG) analysis was performed using the Functional Analysis Tools of the T-REx pipeline

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Other compounds, such as glycolytic inhibitors, carbohydrate and lipid absorption blockers, polyamines, and polyphenols, which collectively modulate pathways regulating the effects of free radicals, are also under consideration