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However, Shang and the team discovered that CRC cell exosomes overexpressing miRNA (miR)-183-5p inhibited the proliferation, invasion, and tube formation ability of microvascular endothelial cells (HMEC-1) by upregulating forkhead box O1 (FOXO1), indicating that overexpressing miR-183-5p exosomes may be a useful therapeutic indicator for CRC (Figure 3) (Shang et al., 2020)

IV therapy in healthy people works only as supportive care

It also suppresses the JNK/AP-1 pathway via phosphorylated c-Jun (p-c-Jun), thereby impeding HCC progression

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Before binding to specific DNA locus antioxidant response elements (AREs), Nrf2 will heterodimerize with Maf or Jun proteins in the nucleus (259, 260)

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