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In the small intestine, bicarbonate secretion from Brnners glands in the duodenum is important for the neutralization of gastric acid

This is a significant advantage from a shelf life perspective

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Specifically, SM/J mice, known for their poor regenerative capacities, displayed early spontaneous onset IDD that was marked by early onset cellular and matrix changes that were consistent with human IDD, such as loss of NP/AF boundary, formation of small clusters in the NP, and chondrocyte-like cells surrounded by proteoglycan-rich matrix (Zhang et al., 2018)

Instead, they focus on energy production

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