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Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia

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For example, when artemisinin is combined with oxaliplatin, the anti-tumor effect of oxaliplatin on esophageal cancer (EC109) cells is enhanced [149]

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doi: 10.1371/journal.pone.0013741 56 DaulatzaiM

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These inhibitors induce ferroptosis by blocking cystine uptake via SLC7A11 and fall under the category of class I ferroptosis inducers

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