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Researchers are particularly interested in its behavior under metabolic stress, where mitochondrial-derived peptides appear to play a regulatory role in how cells adapt energy production to changing demands

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Mitochondrial issues can be triggered by genetics with mutations in key genes that control metabolism, (MTHFR,MTRR, CBS, COMT), viral illness such as CMV, EBV viruses, toxin overload from heavy metals (lead, mercury, thalium, cadmium) and persistent organic pollutants (POP) including PCB, BPA, organophosphate pesticides, and others as well as nutrient deficiency relative to these other issues

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