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MT2A is a cysteine-rich metal-binding protein that chelates mitochondrial copper while leaving total cellular copper unaffected

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Although glycolysis provides a rapid energy supply, it exhibits low glucose utilization efficiency, rendering tumor cells exquisitely sensitive to glucose metabolism perturbations [71]

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Because natural forms of folate (which is folate in reduced form) can cross the bloodbrain barrier via the low-affinity transport mechanism unaffected by FRAA, achieving adequate cerebral folate levels necessitates higher concentrations in the bloodstream

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