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The lack of standardized methods to evaluate total antioxidant capacity and the oxidation state and the use of inadequate antioxidants and/or improper concentrations of antioxidants lead to failure of numerous clinical trials directed to prevent or mitigate progression of atherosclerosis (230233)

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It has long been known to be a potent antioxidant and anti-inflammatory agent, and several published review articles have already detailed these aspects of melatonin

Remarkably, the fruit fly Drosophila melanogaster , expresses a GSTE14 with notable steroid isomerase activity, even though Ser14 has evolved as the active-site residue corresponding to Tyr9 in the mammalian alpha class

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