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For example, reduced NO synthesis further exacerbates oxidative stress and inflammatory responses, leading to the deterioration of endothelial injury (Levine et al., 2012

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ACSL4 initially catalyzes the ligation of AA, with CoA to generate AA-CoA, which are subsequently re-esterified and incorporated into PE by LPCAT3 to form AA-PE

These schemes were adapted from [4]

The higher peak levels may account for the marginally higher adverse events recorded for GLY/DPI