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Here we reviewed the current knowledge on GPCR signaling in cardiac, vascular, and blood cells and highlighted some critical outcomes in PH, such as vasoconstriction/vasodilation responses, vascular inflammation, vascular and cardiac remodeling, and endothelial dysfunction (ED)

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Silibinin also regulates cytokine secretion, increasing IL-12 and IFN- levels while reducing TGF- , SDF-1, IL-6, and TNF- , all of which play crucial roles in immune regulation and anti-cancer immunity in 4T1 breast cancer bearing mice [890]

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