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[DOI] [PMC free article] [PubMed] [Google Scholar] 311.Cheng C.-S., Wang N., Feng Y

doi: 10.1016/S0021-9258(18)50396-3

A further novel finding is that artesunate promoted the activity of catalase and decreased the nicotinamide adenine dinucleotide phosphate (NADPH) protein levels, artesunate inhibited the PI3K and p42/22 MAPK signaling pathways along the way (Ng et al., 2014)
NO is synthesized by NO synthase (NOS) and forms both covalent and noncovalent linkages with target molecules such as proteins

This fibrosis stiffens the heart muscle, reducing its ability to contract and relax effectively, further impairing cardiac function [89]

Shannon, E., Conlon, M
