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Glyoxalases, the key enzymes in the detoxification of methylglyoxal, a byproduct of glycolysis and precursor of advanced glycation end-products, are compromised by oxidation and downregulation

Int Psychogeriatr 23 : 12941300

Reduced drug uptake serves as a primary line of defense, even before other resistance mechanisms develop

Due to the co-fragmentation of multiple precursors with different charge states in DIA, it is not possible to employ the charge-state-dependent collision energy (CE) scaling of DDA

Fonseca, A