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AMKs remarkable effectiveness in neutralizing oxidative agents is reflected by its diffusion-limited reaction rates with free radicals [30,52,54,55,56]

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Liver tissue from Gclc L-KO mice showed enrichment of NRF2 protein and downstream target genes (Fig

In summary, this paradigm shiftfrom viewing amino acids solely as nutrients to recognizing them as integral signaling moleculesprovides a novel conceptual framework for understanding chronic liver disease pathogenesis and opens promising avenues for therapeutic intervention

Hydrogen peroxide production, fate and role in redox signaling of tumor cells

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