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doi: 10.1016/S0006-3223(00)01021-0

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Gath struggled with severe, uncontrollable shaking that made daily tasks like making a cup of coffee nearly impossible

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When safety of the study participants and technological developments allow, so called biomarkers can be used to collect PD data to understand if the drug reaches the target, binds to the target and exerts its expected pharmacological activity within the dose range tested