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Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice

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1g) were observed in both low- and high-dose NAC-treated groups

To validate the presence of these taxa in bile samples, we re-analyzed six 16S rRNA gene sequencing datasets, confirming the presence of 60% of the identified taxa

However, their clinical translation is limited by challenges in intracellular delivery to target cells and the potential for off-target gene silencing effects in non-target tissues

Cyanocobalamin poses additional risks to smokers, and to individuals with methylation, liver or kidney issues, as these conditions can make it difficult to eliminate cyanide