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(IGPP00055) and National Institute of Diabetes and Digestive and Kidney Diseases grants to X.Z
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This creates a dangerous bottleneck where highly toxic Phase I intermediates accumulate in the liver, leading to systemic toxicity, severe hepatic inflammation, and a cascading failure of the body's natural waste-removal systems
doi: 10.1016/j.expneurol.2006.09.004
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